This page includes some tips on how to proficiently use valgrind on gtk/gnome programs. Feel free to add your own tricks or expand the page with more detailed explanations.
Memcheck is the main valgrind tool, it allows to detect memory leaks and other memory management errors. To run a gnome program under memcheck run:
valgrind --tool=memcheck --leak-check=full --leak-resolution=high --num-callers=20 --log-file=vgdump your-program
If the program you are debugging uses dynamically loaded modules with GModule (for instance it has a GModule based plugin system) you should use G_DEBUG=resident-modules to make sure that the modules do not get unloaded and valgrind can retrieve the function names when writing its log:
G_DEBUG=resident-modules valgrind --tool=memcheck --leak-check=full --leak-resolution=high --num-callers=20 --log-file=vgdump your-program
After running the program you can inspect the log in the dump file. The log contains a list of memory related issues and in particular memory leaks. Memory leaks are marked in three ways: definitely lost, possibly lost and still reachable: for a start concentrate on the definitely lost ones, which are bits of memory leaked for sure. For each leak valgrind provides a backtrace which lets you pinpoint exactly where the leaks happens, in particular if your program was compiled with debugging symbols, valgrind will tell you the exact line and file of the leak.
Note: If your binary is really a libtool-generated temporary wrapper, the above command line will run valgrind on your shell which is probably not what you want. Say instead
libtool --mode=execute valgrind --tool=memcheck --leak-check=full --leak-resolution=high --num-callers=20 --log-file=vgdump your-program
Ubuntu users can look at the Ubuntu documentation about Valgrind to know all the details to get Valgrind working.
Use it by sending in --suppressions=gtk.suppression to memcheck
Massif is a memory usage profiler. See this page for an explanation of how to use it in GNOME.
It can be tricky to get Valgrind to run on session-wide programs like Nautilus or gnome-panel. Here is how to do it.